Endocrine Abstracts

Introduction: Amiodarone, a drug with high iodine content, is commonly associated with thyroid dysfunction. There are two well-recognized forms of amiodarone induced thyrotoxicosis. Thyrotoxicosis due to iodine excess leading to increased thyroid hormone synthesis is referred to as Amiodarone induced thyrotoxicosis type 1 (AIT type 1) whilst thyrotoxicosis due to direct toxic effect (thyroiditis) is known is amiodarone induced thyrotoxicosis Type 2 (AIT type 2). The aim in bot...

A 68-year-old male presented with fatigue and acute onset polyuria and polydipsia. There was no history of headaches, visual symptoms, previous cranial radiations, chemotherapy or CNS infections. Investigations revealed normal fasting glucose, urea, creatinine, liver functions and electrolytes including calcium. Further workup including pituitary profile, paired osmolalities and water deprivation test confirmed hypopituitarism and cranial diabetes insipidus (Table 1). The unde...

61-year-old previously fit and healthy female presented with one-week history of confusion and altered consciousness. There was no history of fever, headache or limb weakness. She was dehydrated, Glasgow Coma Scale score was 11/15, pupils were equal and reactive to light bilaterally and rest of examination was unremarkable. Initial investigations are outlines in Table 1. X-ray-chest showed mediastinal lymphadenopathy and CT head was unremarkable. She was initially treated for ...

66 year old patient was diagnosed with macroprolactinoma and started on treatment with Cabergoline at a dose 250 μg twice weekly. Initial echocardiogram was normal and CT chest showed clear lung fields except mild left upper zone consolidation. During a routine follow up appointment 8 months after the initiation of treatment, the blood tests showed abnormal renal function and prolactin level was controlled. CT KUB showed features suggestive of retroperitoneal fibrosis lea...

AimTo assess relationship between serum calcium level and localization studies and management outcome.MethodologyRetrospective analysis of data for patients referred by primary care for hypercalcemia from 1/3/2019 to 1/3/2020 to the Endocrinology department at Royal Berkshire Hospital. The sample size was 63 which excluded normo-calcemic hyperparathyroidism as well as MEN1/2 patients.Re...

We present an interesting case of a 50-year-old woman with previous history of alcohol dependence, depression & oesophagitis who was brought to the emergency department by ambulance with vomiting, back pain and feeling generally unwell. Her GCS was 14/15, HR128/min, RR 32/min, BP 111/60, temperature 35.2 & CBG 11.2mmol. She reported consuming one bottle of Vodka every day. Initial venous blood gas analysis showed severe metabolic acidosis (pH 6.79, HCO3 3, Lactate 15, ...

Suppression of Cytokine Signalling-3 (SOCS-3) modulates the inflammatory pathways responsible for vascular stability by playing a role in inflammatory pathway. It acts by inhibiting the activation of Janus kinase-signal transducer and activating of transcription (JAK-STAT) pathway to transmit their information into the cell nucleus. Therefore, this study aimed to estimate SOCS-3 levels in 2 nd trimester pregnant females and correlate it with blood pressure. A case control stud...

Teddy is a highly proliferative goat breed, as females of this breed are famous for high twinning rates. Feed supplementation of olive oil has been shown to improve semen quality of goat bucks. In this study, the effects of feed supplementation with olive oil on serum testosterone, triiodothyronine (T3), thyroxine (T4) and some biochemical metabolites in Teddy goat bucks were investigated. For this purpose, 9 adult male goats, with clinically normal reproduc...

Teddy is a highly proliferative goat breed, as females of this breed are famous for high twinning rates. Feed supplementation of olive oil has been shown to improve semen quality of goat bucks. In this study, the effects of feed supplementation with olive oil on serum testosterone, triiodothyronine (T3), thyroxine (T4) and some biochemical metabolites in Teddy goat bucks were investigated. For this purpose, 9 adult male goats, with clinically normal reproduc...

Fibrous dysplasia (FD) is a rare bone disease which usually presents to Endocrinologists as part of McCune albright syndrome or as precocious puberty. A variety of other co-morbidities have been described for FD including renal phophate wasting secondary to an excess of FGF23; abnormal thryoid and growth hormone production and abnormal cortisol production. A large number of children are referred to our Regional Sarcoma Service with lytic bony lesions, many of which are subsequ...